Human LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for LIMS2
proveedor
Abbexareference
abx531034Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
LIMS2, also known as PINCH2, is a LIM domain-containing protein closely related to LIMS1. It functions as a key regulator of integrin-mediated signaling, focal adhesion formation, and cytoskeletal organization by interacting with ILK and other focal adhesion proteins. LIMS2 is expressed in a variety of tissues, including muscle and connective tissues, where it supports processes like cell adhesion, migration, and mechanotransduction. It is critical for proper tissue development and maintenance, particularly in skeletal muscle and cardiovascular tissues. LIMS2 is functionally redundant with LIMS1 but has unique roles in fine-tuning integrin signaling. Dysregulation of LIMS2 has been linked to muscular dystrophies, fibrosis, and cancer progression due to defects in cellular adhesion and mechanical force transduction. Knockdown studies reveal defects in cell spreading, migration, and integrin stability, underscoring its role in maintaining structural and mechanical integrity.
Características del producto
category
ELISA Kits
immunogen target
LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
LGMD2W,MDRCMTT,PINCH-2,PINCH2,LIM and senescent cell antigen-like-containing domain protein 2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
LIMS2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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