LIMS2 Antibody
442€ (200 µl)
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name
LIMS2 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432929
tested applications
P-ELISA, IHC
Description
LIMS2 Antibody is a Goat Polyclonal antibody against LIMS2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: LIMS2 Immunogen: abx616389 - Internal region: C-RWSNMSDALA |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/8000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 55679 |
| NCBI Accession | NP_001129509.2, NP_001154875.1 |
| Alias | LGMD2W,MDRCMTT,PINCH-2,PINCH2,LIM and senescent cell antigen-like-containing domain protein 2 |
| Background | Antibody anti-LIMS2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
LIMS2, also known as PINCH2, is a LIM domain-containing protein closely related to LIMS1. It functions as a key regulator of integrin-mediated signaling, focal adhesion formation, and cytoskeletal organization by interacting with ILK and other focal adhesion proteins. LIMS2 is expressed in a variety of tissues, including muscle and connective tissues, where it supports processes like cell adhesion, migration, and mechanotransduction. It is critical for proper tissue development and maintenance, particularly in skeletal muscle and cardiovascular tissues. LIMS2 is functionally redundant with LIMS1 but has unique roles in fine-tuning integrin signaling. Dysregulation of LIMS2 has been linked to muscular dystrophies, fibrosis, and cancer progression due to defects in cellular adhesion and mechanical force transduction. Knockdown studies reveal defects in cell spreading, migration, and integrin stability, underscoring its role in maintaining structural and mechanical integrity.
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