Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 5 (LILRB5) Protein
416€ (20 µg)
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935106861
info@markelab.com
name
Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 5 (LILRB5) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694226
tested applications
SDS-PAGE
Description
Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 5 (LILRB5) Protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 50.27 kDa Observed MW (SDS-PAGE): 70 kDa Sequence Fragment: Met1-Gly458 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >95% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | O75023 |
| Gene ID | 199 |
| OMIM | 64814 |
| Alias | Leukocyte immunoglobulin-like receptor subfamily B member 5,LIR8,CD85C,LIR-8,CD85 antigen-like family member C,Leukocyte immunoglobulin-like receptor 8 |
| Background | Protein LILRB5 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
LILRB5 (Leukocyte Immunoglobulin-Like Receptor B5), also known as ILT7 or CD85c, is part of the LILR (leukocyte immunoglobulin-like receptor) family, which plays a pivotal role in immune regulation. The LILR family includes activating and inhibitory receptors expressed on immune cells, primarily myeloid cells. LILRB5, an inhibitory receptor, is encoded within a highly polymorphic region on chromosome 19q13.4. The inhibitory receptors in this family, including LILRB5, interact with major histocompatibility complex (MHC) molecules and other ligands, modulating imm une responses and promoting tolerance, particularly in tissues prone to autoimmune inflammation or where immune homeostasis is critical. LILRB5 expression is seen in monocytes, macrophages, neutrophils, and dendritic cells. Its function is primarily to transmit inhibitory signals that suppress overactive immune responses, which helps protect tissues from damage during prolonged immune activation or chronic inflammatory diseases
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