Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 5 (LILRB5) Protein

Background

LILRB5 (Leukocyte Immunoglobulin-Like Receptor B5), also known as ILT7 or CD85c, is part of the LILR (leukocyte immunoglobulin-like receptor) family, which plays a pivotal role in immune regulation. The LILR family includes activating and inhibitory receptors expressed on immune cells, primarily myeloid cells. LILRB5, an inhibitory receptor, is encoded within a highly polymorphic region on chromosome 19q13.4. The inhibitory receptors in this family, including LILRB5, interact with major histocompatibility complex (MHC) molecules and other ligands, modulating imm une responses and promoting tolerance, particularly in tissues prone to autoimmune inflammation or where immune homeostasis is critical. LILRB5 expression is seen in monocytes, macrophages, neutrophils, and dendritic cells. Its function is primarily to transmit inhibitory signals that suppress overactive immune responses, which helps protect tissues from damage during prolonged immune activation or chronic inflammatory diseases