Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 (LILRB3) Protein
312€ (20 µg)
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935106861
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name
Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 (LILRB3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694128
tested applications
SDS-PAGE
Description
Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 (LILRB3) Protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 46.1 kDa Observed MW (SDS-PAGE): 70 kDa Sequence Fragment: Met1-Glu443 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >95% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | O75022 |
| OMIM | 6482 |
| Alias | Leukocyte immunoglobulin-like receptor subfamily B member 3,Leukocyte immunoglobulin-like receptor 3,HL9,ILT5,LIR3,PIRB,CD85A,ILT-5,LIR-3,PIR-B,LILRA6,CD85 antigen-like family member A,Immunoglobulin-like transcript 5,Monocyte inhibitory receptor HL9 |
| Background | Protein LILRB3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
LILRB3 (Leukocyte Immunoglobulin-Like Receptor B3) is a member of the leukocyte immunoglobulin-like receptor (LILR) family, a group of receptors involved in regulating the immune response. LILRB3, also known as CD85A or ILT5 (Immunoglobulin-like Transcript 5), is predominantly expressed on myeloid cells, including monocytes, macrophages, neutrophils, and dendritic cells. These receptors play a crucial role in immune regulation by mediating inhibitory signals that prevent excessive activation of the immune system, contributing to the maintenance of immune homeostasis. LILRB3 belongs to the inhibitory subfamily of LILR receptors, which means it primarily dampens immune responses. It achieves this through the recruitment of tyrosine phosphatases, which inhibit activating signaling pathways, thereby reducing inflammatory responses and promoting immune tolerance. This regulation is important for preventing autoimmune reactions and minimizing tissue damage during inflammatory processes.
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