Human Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 2 (LILRA2) Protein
234€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 2 (LILRA2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067776
tested applications
WB, SDS-PAGE
Description
Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 2 (LILRA2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Leukocyte Immunoglobulin Like Receptor Subfamily A, Member 2 (LILRA2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 27.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val217-Leu438 Tag: N-terminal His tag |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N149 |
| Alias | Leukocyte immunoglobulin-like receptor subfamily A member 2,ILT1,LIR7,CD85H,LIR-7,Immunoglobulin-like transcript 1,Leukocyte immunoglobulin-like receptor 7 |
| Background | Protein LILRA2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
LILRA2, also known as Leukocyte Immunoglobulin-Like Receptor A2 (LILRA2) or CD85h, is a member of the immunoglobulin superfamily and part of the leukocyte immunoglobulin-like receptor (LILR) family. This receptor is encoded by the LILR gene cluster on chromosome 19q13.4, which is home to various immunoglobulin-like receptors involved in immune regulation. LILRA2 plays an activating role in immune response modulation and is predominantly expressed on monocytes, macrophages, and some other leukocyte subsets, such as granulocytes. It is essential in host defense, participating in immune responses to infections and modulating inflammation through cellular signaling pathways. The receptor interacts with a variety of ligands, likely including MHC class I molecules, which allows it to influence both innate and adaptive immunity. The immune-modulating role of LILRA2 makes it an essential subject of study in the context of immune responses and inflammation. Unlike other LILR members that may provide inhibitory signaling, LILRA2 is classified as an activating receptor, generally enhancing immune responses through its interaction with signaling adaptors that contain immunoreceptor tyrosine-based activation motifs (ITAMs). This activating function of LILRA2 contrasts with some members of the LILRB subfamily, which contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and thus help suppress immune responses. Research has shown that aberrant expression or dysregulation of LILRA2 can contribute to inflammatory diseases, autoimmunity, and potentially cancer, making it a focal point for therapeutic interventions.
Related Products
Human LILRA2 (Leukocyte immunoglobulin-like receptor subfamily A member 2) ELISA Kit
Ver Producto
