Human Leptin Receptor (LEPR) Protein

Este producto es parte de LEPR - leptin receptor
Human Leptin Receptor (LEPR) Protein
598€ (50 µg)

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Name
Human Leptin Receptor (LEPR) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx651539
Tested Applications
WB, SDS-PAGE

Description

Human Leptin Receptor (LEPR) Protein is a Human protein produced in 293F cells.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Leptin Receptor (LEPR)
Host
293F cells
Assay Type
Activity: Not tested
Sequence Fragment: Phe22-Asp839
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 95.1 kDa  Observed MW: 95 kDa
Expression
Recombinant
Purity
> 98%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
P48357
Alias
OBR,OB-R,CD295,LEP-R,LEPRD,HuB219,OB receptor
Background
Protein LEPR
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

The leptin receptor (LEPR) is a cell surface receptor that plays a central role in energy homeostasis, metabolism, and body weight regulation. LEPR is the receptor for leptin, a hormone primarily secreted by adipose (fat) tissue that signals satiety and energy sufficiency to the brain. Leptin and its receptor are fundamental to regulating food intake, body weight, and energy expenditure. When leptin binds to LEPR, it triggers a cascade of intracellular signals that inform the central nervous system about the body's energy reserves, particularly in the hypothalamus, which then influences appetite suppression, metabolism, and other endocrine functions. LEPR is essential in maintaining homeostatic control over body mass, as dysregulation or mutations in the leptin receptor pathway can lead to obesity, diabetes, and metabolic syndrome.

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