Human Leptin (LEP) Protein
351€ (100 µg)
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Name
Human Leptin (LEP) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx060295
Tested Applications
ELISA, SDS-PAGE
Description
Leptin Protein is a Recombinant protein from Human.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Leptin (LEP) |
| Host | E. coli |
| Origin | Human |
| Observed MW | 19 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, SDS-PAGE |
| Buffer | 500mM NaCl, purified by Ni column. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20 °C or -80°C for long term. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41159 |
| Gene ID | 3952 |
| OMIM | 164160 |
| Alias | OB,OBS,LEPD,Obese protein,Obesity factor |
| Background | Protein LEP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Leptin ( LEP) is an adipokine predominantly produced by adipocytes that plays a key role in regulating energy balance, appetite, and metabolism by acting on the hypothalamus Leptin signals through its receptor (LEPR) to suppress food intake and promote energy expenditure, maintaining body weight homeostasis Circulating leptin levels are proportional to fat mass, with increased levels observed in obesity due to leptin resistance Dysregulation of leptin signaling is associated with metabolic syndrome, type 2 diabetes, and cardiovascular diseases Leptin also exerts immunomodulatory functions, influencing the activity of T cells, macrophages, and other immune cells to enhance pro-inflammatory responses It is implicated in autoimmune diseases, including rheumatoid arthritis and lupus, where elevated leptin promotes chronic inflammation Leptin’s role extends to bone metabolism, reproductive function, and wound healing, highlighting its pleiotropic effects in energy homeostasis and systemic physiology
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