Human Large Neutral Amino Acid Transporter 1 / LAT1 (SLC7A5) Protein
1872€ (1 mg)
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935106861
info@markelab.com
name
Human Large Neutral Amino Acid Transporter 1 / LAT1 (SLC7A5) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654149
tested applications
WB, SDS-PAGE
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Large Neutral Amino Acid Transporter 1 / LAT1 (SLC7A5) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Large neutral amino acids transporter small subunit 1,4F2 light chain,E16,CD98,LAT1,4F2LC,MPE16,D16S469E,CD98 light chain,Integral membrane protein E16 |
| Background | Protein SLC7A5 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SLC7A5, also known as LAT1 (L-type amino acid transporter 1), is a transmembrane protein crucial for amino acid transport across the plasma membrane. It is part of the solute carrier family 7 (SLC7), specifically associated with the transport of large neutral amino acids (LNAAs) like leucine, isoleucine, valine, phenylalanine, and tryptophan, which are essential for various cellular functions. LAT1 is a high-affinity, sodium-independent transporter and functions as part of a heteromeric complex with SLC3A2 (4F2hc or CD98), which acts as a chaperone protein for the proper membrane localization and functionality of LAT1. SLC7A5 plays a significant role in cellular growth and proliferation, and it is highly expressed in rapidly dividing cells. It is abundant in tissues with high metabolic demands, such as the brain, placenta, and certain immune cells, as well as in many cancer cell types, where it facilitates the increased amino acid demand required for protein synthesis and tumor growth. LAT1 is also integral to the blood-brain barrier, as it enables the transport of essential amino acids into the brain, thereby impacting neurotransmitter synthesis.
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