Human L-Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase (AASDHPPT) Protein
234€ (10 µg)
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935106861
info@markelab.com
name
Human L-Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase (AASDHPPT) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166818
tested applications
WB, SDS-PAGE
Description
Aminoadipate Semialdehyde Phosphopantetheinyl Transferase Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | L-Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase (AASDHPPT) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 39.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ser309 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AASD-PPT,ACPS,CGI-80,LYS2,LYS5 |
| Background | Protein AASDHPPT |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
L-Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase (AASDHPPT) is a bifunctional enzyme involved in lysine degradation and coenzyme A biosynthesis. It catalyzes the oxidation of L-aminoadipate semialdehyde to L-aminoadipate and facilitates the attachment of a 4'-phosphopantetheinyl group to carrier proteins, a key step in activating proteins involved in fatty acid and polyketide synthesis. AASDHPPT is expressed ubiquitously but is particularly active in mitochondria, where lysine degradation contributes to cellular energy metabolism and detoxification. Dysregulation of AASDHPPT is associated with metabolic conditions linked to impaired amino acid catabolism, such as glutaric aciduria type 1. Its dual function also highlights its importance in fatty acid metabolism, and mutations affecting AASDHPPT activity may lead to energy imbalances and oxidative stress. Therapeutic approaches targeting AASDHPPT are being explored for metabolic disorders and mitochondrial dysfunction.
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