AASDHPPT antibody
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Description
Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:5000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 36 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NRN7 |
| Gene ID | 60496 |
| Alias | AASD-PPT,ACPS,CGI-80,LYS2,LYS5 |
| Background | Antibody anti-AASDHPPT |
| Status | RUO |
| Note | Mol. Weight 36 kDa |
Descripción
L-Aminoadipate-Semialdehyde Dehydrogenase-Phosphopantetheinyl Transferase (AASDHPPT) is a bifunctional enzyme involved in lysine degradation and coenzyme A biosynthesis. It catalyzes the oxidation of L-aminoadipate semialdehyde to L-aminoadipate and facilitates the attachment of a 4'-phosphopantetheinyl group to carrier proteins, a key step in activating proteins involved in fatty acid and polyketide synthesis. AASDHPPT is expressed ubiquitously but is particularly active in mitochondria, where lysine degradation contributes to cellular energy metabolism and detoxification. Dysregulation of AASDHPPT is associated with metabolic conditions linked to impaired amino acid catabolism, such as glutaric aciduria type 1. Its dual function also highlights its importance in fatty acid metabolism, and mutations affecting AASDHPPT activity may lead to energy imbalances and oxidative stress. Therapeutic approaches targeting AASDHPPT are being explored for metabolic disorders and mitochondrial dysfunction.
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AASDHPPT antibody
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