Human Killer cell lectin-like receptor subfamily B member 1 (KLRB1) Protein

Este producto es parte de KLRB1 - killer cell lectin like receptor B1
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234€ (1 µg)

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935106861
info@markelab.com
name
Human Killer cell lectin-like receptor subfamily B member 1 (KLRB1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx680128
tested applications
SDS-PAGE

Description

Human Killer cell lectin-like receptor subfamily B member 1 (KLRB1) Protein is a recombinant protein produced in Sf9, Baculovirus cells.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Killer cell lectin-like receptor subfamily B member 1 (KLRB1)
Host
Insect
Origin
Human
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 90% (SDS-PAGE)
Size 1
1 µg
Size 2
5 µg
Size 3
50 µg
Form
Liquid 
Tested Applications
SDS-PAGE
Availability
Shipped within 5-10 working days.
Dry Ice
No
Alias
Killer cell lectin-like receptor subfamily B member 1,NKR,CD161,CLEC5B,NKR-P1,NKRP1A,NKR-P1A,hNKR-P1A,C-type lectin domain family 5 member B,Natural killer cell surface protein P1A
Background
Protein KLRB1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Killer cell lectin-like receptor B1 (KLRB1), also known as CD161, is a type II transmembrane protein predominantly expressed on subsets of immune cells, especially natural killer (NK) cells and T cells. KLRB1 plays a key role in modulating immune responses and is especially involved in the regulation of cytotoxicity and cytokine production, particularly among NK and T cell subsets. KLRB1 belongs to the C-type lectin superfamily and is encoded by the KLRB1 gene located on chromosome 12p13 in humans. KLRB1’s expression is associated with an inhibitory effect on immune cell activation, helping maintain immune homeostasis, prevent excessive immune responses, and aid in the modulation of immune activity against infections, tumors, and in inflammatory diseases. KLRB1 is primarily known for its role as a receptor for the carbohydrate-bearing protein LLT1 (lectin-like transcript 1, or CLEC2D). This interaction facilitates cell-cell communication and can mediate inhibitory signaling in NK cells and some T cell subsets, potentially leading to immune tolerance in certain tissues and tumors.

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