Human Killer Cell Lectin-Like Receptor Subfamily B Member 1 (KLRB1) Protein

Name: Human Killer Cell Lectin-Like Receptor Subfamily B Member 1 (KLRB1) Protein
Brand: Abbexa
SKU: abx067655
Price: 234 EUR
Availability: OnlineOnly

Este producto es parte de KLRB1 - killer cell lectin like receptor B1

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein KLRB1

proveedor

Abbexa

reference

abx067655

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Background

Killer cell lectin-like receptor B1 (KLRB1), also known as CD161, is a type II transmembrane protein predominantly expressed on subsets of immune cells, especially natural killer (NK) cells and T cells. KLRB1 plays a key role in modulating immune responses and is especially involved in the regulation of cytotoxicity and cytokine production, particularly among NK and T cell subsets. KLRB1 belongs to the C-type lectin superfamily and is encoded by the KLRB1 gene located on chromosome 12p13 in humans. KLRB1’s expression is associated with an inhibitory effect on immune cell activation, helping maintain immune homeostasis, prevent excessive immune responses, and aid in the modulation of immune activity against infections, tumors, and in inflammatory diseases. KLRB1 is primarily known for its role as a receptor for the carbohydrate-bearing protein LLT1 (lectin-like transcript 1, or CLEC2D). This interaction facilitates cell-cell communication and can mediate inhibitory signaling in NK cells and some T cell subsets, potentially leading to immune tolerance in certain tissues and tumors.

Características del producto

origin

Human

host

E. coli

immunogen target

Killer Cell Lectin-Like Receptor Subfamily B Member 1 (KLRB1)

host

E. coli

conjugation

Unconjugated

form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

tested applications

WB, SDS-PAGE

size 1

10 µg

size 2

50 µg

size 3

100 µg

size 4

200 µg

size 5

500 µg

observerd MW

Molecular Weight: Calculated MW: 17.3 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys73-Ser188 Tag: N-terminal His tag

expression

Recombinant

purity

> 95%

buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

or code

KLRB1

dry ice

availability

Shipped within 5-7 working days.

alias

Killer cell lectin-like receptor subfamily B member 1,NKR,CD161,CLEC5B,NKR-P1,NKRP1A,NKR-P1A,hNKR-P1A,C-type lectin domain family 5 member B,Natural killer cell surface protein P1A

uniprot id

https://www.uniprot.org/uniprotkb/Q12918

note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

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Killer Cell Lectin-Like Receptor Subfamily B Member 1 (KLRB1) Antibody

proveedor

Abbexa

reference

abx006405

Tested Applications

ELISA, WB

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

KLRB1 Antibody is a Rabbit Polyclonal Antibody against KLRB1.

195€ (20 µl)