Human Killer cell lectin-like receptor subfamily B member 1 (KLRB1) ELISA Kit

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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for KLRB1
proveedor
Abbexareference
abx530247Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Killer cell lectin-like receptor subfamily B member 1 (KLRB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Killer cell lectin-like receptor subfamily B member 1 (KLRB1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Killer cell lectin-like receptor B1 (KLRB1), also known as CD161, is a type II transmembrane protein predominantly expressed on subsets of immune cells, especially natural killer (NK) cells and T cells. KLRB1 plays a key role in modulating immune responses and is especially involved in the regulation of cytotoxicity and cytokine production, particularly among NK and T cell subsets. KLRB1 belongs to the C-type lectin superfamily and is encoded by the KLRB1 gene located on chromosome 12p13 in humans. KLRB1’s expression is associated with an inhibitory effect on immune cell activation, helping maintain immune homeostasis, prevent excessive immune responses, and aid in the modulation of immune activity against infections, tumors, and in inflammatory diseases. KLRB1 is primarily known for its role as a receptor for the carbohydrate-bearing protein LLT1 (lectin-like transcript 1, or CLEC2D). This interaction facilitates cell-cell communication and can mediate inhibitory signaling in NK cells and some T cell subsets, potentially leading to immune tolerance in certain tissues and tumors.
Características del producto
category
ELISA Kits
immunogen target
Killer cell lectin-like receptor subfamily B member 1 (KLRB1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
Killer cell lectin-like receptor subfamily B member 1,NKR,CD161,CLEC5B,NKR-P1,NKRP1A,NKR-P1A,hNKR-P1A,C-type lectin domain family 5 member B,Natural killer cell surface protein P1A
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
KLRB1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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