Human Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) Protein
247€ (10 µg)
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935106861
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name
Human Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067654
tested applications
WB, SDS-PAGE
Description
Human Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Killer Cell Immunoglobulin Like Receptor 3DL3 (KIR3DL3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 78.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp147-Val410 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N743 |
| Alias | KIR44,KIRC1,CD158Z,KIR3DL7,KIR2DL5B,CD158 antigen-like family member Z,Killer cell inhibitory receptor 1 |
| Background | Protein KIR3DL3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Killer Cell Immunoglobulin-Like Receptor 3DL3 (KIR3DL3), another member of the KIR family, is expressed primarily on NK cells and a subset of T cells, contributing to the modulation of innate and adaptive immune responses. While less well-characterized than other KIR family members, KIR3DL3 is thought to provide inhibitory signals upon binding to its ligands, which include specific HLA class I molecules. Its expression and function are tightly regulated, and genetic studies suggest a role in immune system variability, with potential implications in transplantation immunology and disease susceptibility. Emerging research is exploring the relevance of KIR3DL3 in the context of immune evasion by tumors and infectious agents, emphasizing its potential as a target for enhancing immune responses in therapeutic settings.
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