Human Killer Cell Immunoglobulin-Like Receptor 2Dl5A (KIR2DL5A) Protein
377€ (20 µg)
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935106861
info@markelab.com
name
Human Killer Cell Immunoglobulin-Like Receptor 2Dl5A (KIR2DL5A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694130
tested applications
SDS-PAGE
Description
Killer Cell Immunoglobulin-Like Receptor 2Dl5A (KIR2DL5A) protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Killer Cell Immunoglobulin-Like Receptor 2Dl5A (KIR2DL5A) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-His240 Tag: C-terminal His tag |
| Origin | Human |
| Observed MW | Calculated MW: 23.5 kDa Observed MW (SDS-PAGE): 42 kDa |
| Expression | Recombinant |
| Purity | >85% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Size 3 | 500 µg |
| Size 4 | 1 mg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q8N109 |
| OMIM | 6535 |
| Alias | CD158F,KIR2DL5,KIR2DL5.1,KIR2DL5.3 |
| Background | Protein KIR2DL5A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile H2O. Do not vortex. |
Descripción
Killer cell immunoglobulin-like receptor 2DL5A (KIR2DL5A) is a member of the KIR family, which plays a crucial role in immune regulation, especially in natural killer (NK) cell and some T-cell activities. These receptors allow immune cells to differentiate between normal cells and those that may be infected, stressed, or malignant. KIR2DL5A, like other inhibitory KIR receptors, is known for its role in maintaining immune tolerance by providing inhibitory signals to prevent NK cells from attacking healthy tissues. This regulation is achieved through interactions with specific ligands, mainly human leukocyte antigen (HLA) class I molecules on target cells. However, the specific HLA ligands for KIR2DL5A remain under research, with some studies suggesting unique ligand interactions within this receptor subtype. KIR2DL5A is located on chromosome 19 within the KIR gene cluster, which exhibits considerable genetic diversity across individuals. This diversity allows NK cells to adapt to various pathogenic and environmental pressures. The polymorphic nature of KIR genes like KIR2DL5A contributes to variations in immune responses between individuals, which can influence susceptibility to infections, autoimmune diseases, and cancer.
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