Human Killer Cell Immunoglobulin-Like Receptor 2Dl5A (KIR2DL5A) Protein
416€ (20 µg)
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935106861
info@markelab.com
name
Human Killer Cell Immunoglobulin-Like Receptor 2Dl5A (KIR2DL5A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694130
tested applications
SDS-PAGE
Description
Human Killer Cell Immunoglobulin-Like Receptor 2Dl5A (KIR2DL5A) Protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 23.5 kDa Observed MW (SDS-PAGE): 42 kDa Sequence Fragment: Met1-His240 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >85% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | Q8N109 |
| OMIM | 6535 |
| Alias | CD158F,KIR2DL5,KIR2DL5.1,KIR2DL5.3 |
| Background | Protein KIR2DL5A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Killer cell immunoglobulin-like receptor 2DL5A (KIR2DL5A) is a member of the KIR family, which plays a crucial role in immune regulation, especially in natural killer (NK) cell and some T-cell activities. These receptors allow immune cells to differentiate between normal cells and those that may be infected, stressed, or malignant. KIR2DL5A, like other inhibitory KIR receptors, is known for its role in maintaining immune tolerance by providing inhibitory signals to prevent NK cells from attacking healthy tissues. This regulation is achieved through interactions with specific ligands, mainly human leukocyte antigen (HLA) class I molecules on target cells. However, the specific HLA ligands for KIR2DL5A remain under research, with some studies suggesting unique ligand interactions within this receptor subtype. KIR2DL5A is located on chromosome 19 within the KIR gene cluster, which exhibits considerable genetic diversity across individuals. This diversity allows NK cells to adapt to various pathogenic and environmental pressures. The polymorphic nature of KIR genes like KIR2DL5A contributes to variations in immune responses between individuals, which can influence susceptibility to infections, autoimmune diseases, and cancer.
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