Human Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) Protein
247€ (10 µg)
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name
Human Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690019
tested applications
SDS-PAGE
Description
Human killer cell immunoglobulin-like receptor 2DL3 Protein is a recombinant protein from Human produced in Human Cells. Recombinant Human killer cell immunoglobulin-like receptor 2DL3 is produced by our Mammalian expression system and the target gene encoding His22-His245 is expressed with a 6His tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | killer cell immunoglobulin-like receptor 2DL3 |
| Host | Human |
| Origin | Human |
| Observed MW | Molecular Weight: 25.4 kDa Sequence Fragment: His22-His245 Tag: C-terminal 6 His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | PBS, pH7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| NCBI Accession | AAX23102.1 |
| Alias | CD158 antigen-like family member B2,KIR-023GB,Killer inhibitory receptor cl 2-3,NKAT2a,NKAT2b,GL183,CD158b,KIR2DL |
| Background | Protein KIR2DL3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
KIR2DL3 is an inhibitory receptor that is part of the killer cell immunoglobulin-like receptor (KIR) family, which is primarily expressed on natural killer (NK) cells and some T-cell subsets. This receptor plays a pivotal role in immune surveillance and modulation by binding to specific HLA class I molecules, particularly HLA-C alleles, on potential target cells. KIR2DL3 recognizes HLA-C1 (characterized by an asparagine at position 80), which is different from HLA-C2 (lysine at position 80) recognized by related receptors like KIR2DL1. By binding to HLA-C1, KIR2DL3 sends inhibitory signals that regulate NK cell cytotoxicity, promoting immune tolerance and minimizing the risk of autoimmunity. The KIR genes, including KIR2DL3, are located on chromosome 19q13.4 in a highly polymorphic region known as the leukocyte receptor complex (LRC). Genetic variability within this complex, particularly in the KIR2DL3 and its HLA-C ligands, contributes to diversity in immune response among individuals. Variants in KIR2DL3 and other KIR genes are associated with differential susceptibility to diseases, including autoimmune disorders, viral infections, and cancers.
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