Human Karyopherin Alpha 3 (KPNa3) Protein
221€ (10 µg)
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name
Human Karyopherin Alpha 3 (KPNa3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650028
tested applications
WB, SDS-PAGE
Description
Human KPNa3 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Karyopherin Alpha 3 (KPNa3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 28.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu3-Val220 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00505 |
| Alias | QIP2,Importin alpha Q2,Importin subunit alpha-4,SRP1,SRP4,IPOA4,SPG88; Hsrp1,SRP1gamma |
| Background | Protein KPNa3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
KPNA3, or importin-α3, is another member of the importin-α family that mediates the nuclear import of cargo proteins with classical nuclear localization signals (NLS). It interacts with importin-β to form a complex that transports cargo proteins through the nuclear pore complex (NPC). KPNA3 is expressed in various tissues and is particularly important in regulating nuclear transport during cell signaling, differentiation, and immune responses. It has roles in viral infections, where it mediates the nuclear import of viral proteins such as influenza and HIV components, aiding viral replication. Dysregulation of KPNA3 is associated with neurological disorders and cancer, where it influences nuclear transport of transcription factors and oncogenes. Knockout and functional studies show its essential role in maintaining cellular homeostasis and regulating nuclear import efficiency during development and stress responses.
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