Human Islet Amyloid Polypeptide (IAPP) Cell ELISA Kit

Este producto es parte de IAPP- Islet Amyloid Polypeptide
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513.5€ (96 tests)

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935106861
info@markelab.com
name
Human Islet Amyloid Polypeptide (IAPP) Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595031
tested applications
ELISA

Description

Amylin Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryELISA Kits
Immunogen TargetIslet Amyloid Polypeptide (IAPP)
ReactivityHuman
Detection MethodColorimetric
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
Size 196 tests
Tested ApplicationsELISA
AvailabilityShipped within 1-2 weeks. The validity for this kit is at least 6 months
StorageShipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry IceNo
UniProt IDP10997
Gene ID3375
OMIM147940
AliasAmylin,IAP,Diabetes-Associated Peptide Diabetes-Associated Peptide
BackgroundElisa kits for IAPP
StatusRUO
NoteValidity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Islet amyloid polypeptide (IAPP), also known as amylin, is a 37-residue peptide hormone produced by the pancreatic beta cells. IAPP plays a role in regulating glucose metabolism, primarily by slowing gastric emptying and reducing glucagon secretion. in conditions such as type 2 diabetes mellitus, IAPP can misfold and aggregate, forming amyloid fibrils. These amyloid fibrils can accumulate in the pancreas, particularly in the islets of Langerhans. This aggregation of amyloid fibrils is associated with beta cell dysfunction, apoptosis , and progression of type 2 diabetes. Amyloid deposits originating from islet amyloid polypeptide (IAPP), are frequently observed in the pancreatic islets of individuals with type 2 diabetes mellitus or those afflicted with insulinoma cancer. Although the connection between amylin and the onset of type 2 diabetes has been recognized for some time, pinpointing its direct causative role has proved challenging. Some research indicates that amylin, and beta-amyloid (Abeta) linked to Alzheimer's disease, could trigger apoptotic cell death in insulin-producing beta cells. This effect may have implications for the progression of type 2 diabetes.

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