Human Interleukin 6 Receptor Subunit Alpha (IL6R) Protein

Este producto es parte de IL6R - Interleukin 6 Receptor
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312€ (20 µg)

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935106861
info@markelab.com
name
Human Interleukin 6 Receptor Subunit Alpha (IL6R) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694181
tested applications
SDS-PAGE

Description

Human Interleukin 6 Receptor Subunit Alpha (IL6R) Protein is a recombinant Human protein expressed in HEK293 cells.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryProteins and Peptides
HostHEK293 cells
OriginHuman
Observed MWMolecular Weight: Calculated MW: 40.04 kDa Observed MW (SDS-PAGE): 70 kDa Sequence Fragment: Met1-Pro365 Tag: C-terminal His tag
ExpressionRecombinant
Purity>95% (SDS-PAGE)
Size 120 µg
Size 2100 µg
FormLyophilized Reconstitute in sterile H2O. Do not vortex.
Tested ApplicationsSDS-PAGE
BufferPrior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80.
AvailabilityShipped within 5-15 working days.
StorageStore lyophilized between -20 °C and -80 °C.
Dry IceNo
UniProt IDP08887
Gene ID357
OMIM14788
AliasIL6Q,gp80,CD126,HIES5,IL-6R,IL6RA,IL6RQ,IL-1Ra,IL-6RA,IL6QTL,IL-6R-1,L-6R-Alpha,IL-6Rα
BackgroundProtein IL6R
StatusRUO
NoteThis product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

IL6R is a key component of the interleukin-6 (IL6) signaling pathway, consisting of a membrane-bound and soluble form (sIL6R), which binds IL6 and mediates downstream effects via the gp130 co-receptor This interaction activates the JAK/STAT3, MAPK, and PI3K/AKT pathways, regulating immune responses, inflammation, and hematopoiesis IL6R signaling is critical in acute-phase responses, B cell maturation, and T cell proliferation Dysregulation of IL6R activity is implicated in chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus (SLE) In cancer, IL6R signaling supports tumor progression, angiogenesis, and immune evasion Therapeutic targeting of IL6R, such as with tocilizumab, is effective in reducing inflammation and cytokine storm in conditions like COVID-19, autoimmune disorders, and hematological malignancies

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