Human Interleukin 6 (IL6) Protein
Pida mas información
935106861
info@markelab.com
Precio
247€ (10 µg)
Protein IL6
proveedor
Abbexareference
abx060189Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Human IL-6 Protein is a recombinant Human protein expressed in E. coli.
Background
IL6 is a pleiotropic cytokine involved in regulating immune responses, inflammation, and hematopoiesis It is produced by macrophages, T cells, fibroblasts, and endothelial cells in response to infections, trauma, or tissue damage IL6 activates downstream signaling through its receptor, IL-6R, and the JAK/STAT3 pathway, driving acute-phase protein synthesis, such as CRP and fibrinogen, and promoting B cell differentiation into plasma cells Dysregulated IL6 expression is associated with chronic inflammation, autoimmune diseases like rheumatoid arthritis, and cancer progression, where it promotes tumor growth, survival, and angiogenesis IL6 also contributes to cytokine storm syndrome in conditions like COVID-19, where excessive IL6 leads to hyperinflammation and organ damage Targeting IL6 signaling with anti-IL6 therapies, such as tocilizumab, has shown efficacy in treating autoimmune diseases and cytokine-driven conditions
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Interleukin 6 (IL6)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute with sterile 18MΩ-cm H2O.
tested applications
SDS-PAGE
size 1
10 µg
size 2
100 µg
observerd MW
Molecular Weight: 21 kDa Concentration: Prior to lyophilization: 2 mg/ml
expression
Recombinant
purity
> 95% (SDS-PAGE). Contains < 1% Dimers (SDS-PAGE)
buffer
Prior to lyophilization: 10 mM phosphate buffer, 200 mM NaCl (pH 7.0). Does not contain preservatives.
storage
Store at -20 °C or -80 °C for up to 2 years. Can be stored at 4 °C for for up to 1 week after reconstitution. It is recommended to add 0.1% HSA or BSA for long-term storage. Avoid repeated freeze/thaw cycles.
or code
IL6
dry ice
No
availability
Shipped within 5-10 working days.
alias
IL-6,BSF,HGF,HSF,IFNB2,CDF,B-cell stimulatory factor 2
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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