Human Interleukin 6 (IL6) Protein
247€ (10 µg)
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name
Human Interleukin 6 (IL6) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx060189
tested applications
SDS-PAGE
Description
Human IL-6 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 6 (IL6) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 21 kDa Concentration: Prior to lyophilization: 2 mg/ml |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE). Contains < 1% Dimers (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute with sterile 18MΩ-cm H2O. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 10 mM phosphate buffer, 200 mM NaCl (pH 7.0). Does not contain preservatives. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at -20 °C or -80 °C for up to 2 years. Can be stored at 4 °C for for up to 1 week after reconstitution. It is recommended to add 0.1% HSA or BSA for long-term storage. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05231 |
| Gene ID | 3569 |
| OMIM | 147620 |
| Alias | IL-6,BSF,HGF,HSF,IFNB2,CDF,B-cell stimulatory factor 2 |
| Background | Protein IL6 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL6 is a pleiotropic cytokine involved in regulating immune responses, inflammation, and hematopoiesis It is produced by macrophages, T cells, fibroblasts, and endothelial cells in response to infections, trauma, or tissue damage IL6 activates downstream signaling through its receptor, IL-6R, and the JAK/STAT3 pathway, driving acute-phase protein synthesis, such as CRP and fibrinogen, and promoting B cell differentiation into plasma cells Dysregulated IL6 expression is associated with chronic inflammation, autoimmune diseases like rheumatoid arthritis, and cancer progression, where it promotes tumor growth, survival, and angiogenesis IL6 also contributes to cytokine storm syndrome in conditions like COVID-19, where excessive IL6 leads to hyperinflammation and organ damage Targeting IL6 signaling with anti-IL6 therapies, such as tocilizumab, has shown efficacy in treating autoimmune diseases and cytokine-driven conditions
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