Human Interleukin-36 Receptor Antagonist Protein (IL36RN) Protein

Este producto es parte de IL36RN - Interleukin-36 receptor antagonist protein
Human Interleukin-36 Receptor Antagonist Protein (IL36RN) Protein

Pida mas información

935106861

info@markelab.com

Precio

260€ (10 µg)

Protein IL36RN

proveedor

Abbexa

reference

abx167179

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Interleukin 1 Delta Protein is a recombinant Human protein expressed in E. coli.


Background

IL36RN, also known as IL-36Ra, is an anti-inflammatory cytokine that functions as a natural inhibitor of IL-36 signaling. It binds to the IL-36 receptor (IL1RL2) and prevents its activation by IL36A, IL36B, and IL36G, thereby blocking downstream NF-κB, MAPK, and JNK signaling pathways. IL36RN is primarily expressed in keratinocytes, epithelial cells, and immune cells, where it regulates inflammation and prevents excessive immune activation at epithelial barriers. It plays a key role in maintaining tissue homeostasis and limiting pathological inflammation in conditions such as psoriasis, where mutations in IL36RN lead to uncontrolled IL-36 activity, severe inflammation, and pustular psoriasis. IL36RN is also implicated in mucosal immunity and inflammatory diseases of the skin, lungs, and gastrointestinal tract. Knockout studies reveal heightened IL-36 signaling, excessive cytokine production, and severe tissue inflammation, underscoring IL36RN's role as a key anti-inflammatory regulator and protective factor in immune homeostasis and barrier tissue health.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Interleukin 1 Delta (IL36RN)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 19.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys12-Phe151 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IL36RN


dry ice

No


availability

Shipped within 5-7 working days.


alias

IL-36Ra,IL-1F5,FIL1, FIL1Delta,IL1F5


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


Quizá le pueda interesar

Mouse FIL1d(Interleukin 1 Delta) ELISA Kit

Mouse FIL1d(Interleukin 1 Delta) ELISA Kit

proveedor

FineTest

reference

EM1025

reactivity

mouse

status

RUO

Precio a consultar

Ver más

anti- IL1F5 antibody

anti- IL1F5 antibody

proveedor

FineTest

reference

FNab04238

Tested Applications

ELISA, WB

reactivity

human

status

RUO

clonality

monoclonal

Precio a consultar

Ver más

Recombinant Mouse IL-36RN

Recombinant Mouse IL-36RN

proveedor

FineTest

reference

P6882

Tested Applications

Western Blot,ELISA

status

RUO

Precio a consultar

Ver más