Human Interleukin 18 Receptor 1 (IL18R1) CLIA Kit
845€ (96 tests)
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935106861
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name
Human Interleukin 18 Receptor 1 (IL18R1) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx492949
tested applications
CLIA
Description
Human Interleukin 18 Receptor 1 (IL18R1) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Interleukin 18 Receptor 1 (IL18R1) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.058 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | L18R1, CD218a, CDw218a,IL-18Ralpha,IL-18 R alpha,IL-1 R5,IL-18RA,IL18RA,IL1RRP |
| Background | CLIA Kits IL18R1 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IL18R1 is a key receptor in the interleukin-18 (IL-18) signaling pathway, mediating pro-inflammatory immune responses and host defense mechanisms. It forms a heterodimeric complex with IL18RAP (Interleukin 18 Receptor Accessory Protein) upon IL-18 ligand binding, leading to the recruitment of the MyD88 adaptor protein and activation of downstream NF-κB, MAPK, and JNK pathways. IL18R1 is highly expressed on immune cells, including T cells, natural killer (NK) cells, and macrophages, where it plays critical roles in cytokine production, immune cell activation, and Th1 immune responses. It contributes to the regulation of inflammation, pathogen defense, and tissue repair in response to infections, stress, and inflammatory stimuli. Dysregulation of IL18R1 is linked to autoimmune diseases, chronic inflammation, and cancers, where excessive IL-18 signaling promotes tissue damage and tumor progression. Knockout studies reveal impaired cytokine production, reduced NK cell activation, and weakened pathogen clearance, underscoring its critical role in innate and adaptive immunity, inflammatory signaling, and immune surveillance.
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