Human Interleukin 12 Receptor Beta 1 (IL12Rb1) ELISA Kit

Este producto es parte de IL12RB1 - interleukin 12 receptor subunit beta 1
Human Interleukin 12 Receptor Beta 1 (IL12Rb1) ELISA Kit
689€ (96 tests)

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Name
Human Interleukin 12 Receptor Beta 1 (IL12Rb1) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx151925
Tested Applications
ELISA

Description

Human Interleukin 12 Receptor Beta 1 (IL12Rb1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human IL12RB1 concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Interleukin 12 Receptor Beta 1 (IL12Rb1)

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Interleukin 12 Receptor Beta 1 (IL12Rb1)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.06 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
IL-12 receptor subunit beta-1,CD212,IMD30,IL12RB,IL-12R-BETA1,IL-12 receptor beta component
Background
Elisa Kits for: IL12RB1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

Interleukin 12 receptor subunit beta 1 (IL12RB1) is a protein that serves as an integral component of the interleukin-12 receptor (IL-12R) complex, a receptor system critical for immune function. IL12RB1 is encoded by the IL12RB1 gene and is highly expressed in immune cells, primarily on T cells, natural killer (NK) cells, and macrophages. It plays a central role in mediating immune responses, specifically by binding to the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23), which are essential for driving Th1-type immune responses and promoting cell-mediated immunity. Through this role, IL12RB1 is key in defending the body against intracellular pathogens such as Mycobacterium tuberculosis and certain viruses. The IL-12R complex comprises two main subunits: IL12RB1 and IL12RB2. IL12RB1 forms a binding receptor for both IL-12 and IL-23, and its expression level and function are vital for proper immune function. Genetic mutations in IL12RB1 are linked to immunodeficiency syndromes, as individuals with these mutations have impaired responses to IL-12 and IL-23, resulting in compromised resistance to infections. The receptor’s functionality is therefore critical for immune cell activation, proliferation, and differentiation, particularly within the adaptive immune response.

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