Human Interleukin 10 (IL10) Protein
247€ (10 µg)
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935106861
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name
Human Interleukin 10 (IL10) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx060171
tested applications
HPLC, SDS-PAGE
Description
Human IL-10 Protein is a recombinant protein from E. Coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | IL10 |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 18.6 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute with sterile 18MΩ-cm H2O. |
| Tested Applications | HPLC, SDS-PAGE |
| Buffer | 10 mM phosphate buffer, 200 mM NaCl (pH 7.0). Does not contain preservatives. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at -20°C or -80°C for 2 years. After reconstituting, it can be stored at 4°C for a week, it is recommended to add 0.1% HSA or BSA for long term. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P22301 |
| Gene ID | 3586 |
| OMIM | 124092 |
| Alias | CSIF,GVHDS,IL-10,IL10A,TGIF,Cytokine synthesis inhibitory factor |
| Background | Protein IL10 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL10 is an anti-inflammatory cytokine produced by macrophages, T regulatory cells, and other immune cells to suppress excessive immune responses and maintain tissue homeostasis IL10 signaling occurs through the IL-10 receptor (IL10R) and activates the JAK/STAT3 pathway, inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL1β, and IL6 It plays a pivotal role in immune tolerance, limiting damage caused by chronic inflammation and infections Dysregulation of IL10 expression is associated with autoimmune diseases, such as Crohn's disease, multiple sclerosis, and psoriasis IL10 also exerts immunosuppressive effects in the tumor microenvironment, facilitating tumor progression and immune evasion due to its inhibitory influence on T cells and antigen-presenting cells IL10-based therapies are being explored for managing inflammatory diseases and promoting immune modulation in cancer and chronic infections
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