Human Interleukin-1 Receptor Type 2 (IL1R2) Protein
273€ (10 µg)
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Name
Human Interleukin-1 Receptor Type 2 (IL1R2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx690058
Tested Applications
SDS-PAGE
Description
Interleukin-1 Receptor Type 2 (IL1R2) protein is a recombinant Human protein expressed in HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin-1 Receptor Type 2 (IL1R2) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Phe14-Glu343 Tag: C-terminal 6 His tag |
| Origin | Human |
| Observed MW | Calculated MW: 38.6 kDa Observed MW (SDS-PAGE): 50 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | 0.2 µm filtered prior to lyophilization. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5%-8% Trehalose, Mannitol and 0.01% Tween 80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | P27930 |
| Gene ID | 7850 |
| OMIM | 147811 |
| Alias | IL1R2,CD121d. IL1 RII |
| Background | Protein IL1R2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
IL1R2 functions as a decoy receptor for interleukin-1, competitively binding to IL-1α, IL-1β, and the IL-1 receptor accessory protein (IL1RAP) without initiating downstream signaling IL1R2 lacks an active intracellular signaling domain, thereby preventing activation of NF-κB and other pro-inflammatory pathways IL1R2 is expressed on the surface of monocytes, macrophages, and B cells, and it is also secreted in a soluble form (sIL1R2), which further neutralizes IL-1 activity in the extracellular environment By acting as a negative regulator of IL-1 signaling, IL1R2 plays an anti-inflammatory role and contributes to the resolution of immune responses IL1R2 expression is upregulated by anti-inflammatory cytokines such as IL-4 and IL-10, highlighting its role in immune regulation Dysregulation of IL1R2 is associated with inflammatory diseases, including sepsis, arthritis, and chronic autoimmune disorders, where its expression may serve as a biomarker for disease activity IL1R2’s ability to limit IL-1 activity makes it a critical target for therapeutic strategies aimed at reducing excessive inflammation and immune activation
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