Human Interleukin 1 Receptor Type II (IL1R2) Protein

Este producto es parte de IL1R - Interleukin 1 Receptor Type
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234€ (10 µg)

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935106861
info@markelab.com
name
Human Interleukin 1 Receptor Type II (IL1R2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690058
tested applications
SDS-PAGE

Description

Human Interleukin-1 receptor type 2 Protein is a recombinant protein from Human produced in Human Cells. Recombinant Human Interleukin-1 receptor type 2/IL-1R-2  is produced by our Mammalian expression system and the target gene encoding Phe14-Glu343 is expressed with a 6His tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Interleukin-1 receptor type 2
Host
Human
Origin
Human
Observed MW
Molecular Weight: 38.6 kDa
Sequence Fragment: Phe14-Glu343
Tag: C-terminal 6 His tag
Expression
Recombinant
Purity
> 95% (SDS-PAGE)
Size 1
10 µg
Size 2
50 µg
Form
Lyophilized
Tested Applications
SDS-PAGE
Buffer
PBS, pH7.4.
Availability
Shipped within 5-15 working days.
Storage
Store at < -20°C.
Dry Ice
No
UniProt ID
P27930
NCBI Accession
NP_004624.1
Alias
IL1R2,CD121d. IL1 RII
Background
Protein IL1R2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

IL1R2 functions as a decoy receptor for interleukin-1, competitively binding to IL-1α, IL-1β, and the IL-1 receptor accessory protein (IL1RAP) without initiating downstream signaling IL1R2 lacks an active intracellular signaling domain, thereby preventing activation of NF-κB and other pro-inflammatory pathways IL1R2 is expressed on the surface of monocytes, macrophages, and B cells, and it is also secreted in a soluble form (sIL1R2), which further neutralizes IL-1 activity in the extracellular environment By acting as a negative regulator of IL-1 signaling, IL1R2 plays an anti-inflammatory role and contributes to the resolution of immune responses IL1R2 expression is upregulated by anti-inflammatory cytokines such as IL-4 and IL-10, highlighting its role in immune regulation Dysregulation of IL1R2 is associated with inflammatory diseases, including sepsis, arthritis, and chronic autoimmune disorders, where its expression may serve as a biomarker for disease activity IL1R2’s ability to limit IL-1 activity makes it a critical target for therapeutic strategies aimed at reducing excessive inflammation and immune activation
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