Human Interleukin 1 Receptor Like Protein 1 (IL1RL1) Protein

Este producto es parte de IL1RL1 - Interleukin 1 Receptor Like Protein 1
Human Interleukin 1 Receptor Like Protein 1 (IL1RL1) Protein

Pida mas información

935106861

info@markelab.com

Precio

225€ (10 µg)

Protein IL1RL1

proveedor

Abbexa

reference

abx067413

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Interleukin 1 Receptor Like Protein 1 (IL1RL1) is a recombinant Human protein produced in E. coli using Prokaryotic expression.


Background

IL1RL1, also known as ST2, is a member of the IL-1 receptor family that serves as the receptor for interleukin-33 (IL-33), a cytokine involved in type 2 immune responses, tissue repair, and inflammation. IL1RL1 exists in both membrane-bound and soluble isoforms, where the membrane-bound form (ST2L) mediates IL-33 signaling, while the soluble form (sST2) acts as a decoy receptor to neutralize IL-33 activity. Upon IL-33 binding, IL1RL1 forms a heterodimeric complex with IL1RAP, leading to the activation of NF-κB, ERK, and p38 MAPK signaling pathways, which promote cytokine production and immune cell activation. IL1RL1 is highly expressed on Th2 cells, mast cells, eosinophils, and innate lymphoid cells, where it regulates allergic inflammation, tissue homeostasis, and host defense. Dysregulation of IL1RL1 is implicated in allergic asthma, atopic dermatitis, cardiovascular diseases, and fibrotic disorders, where excessive IL-33 signaling drives pathological inflammation and tissue remodeling. Functional studies show that loss of IL1RL1 results in impaired type 2 immune responses, reduced cytokine production, and defective tissue repair, emphasizing its role in immune regulation, inflammation, and tissue homeostasis.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Interleukin 1 Receptor Like Protein 1 (IL1RL1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

1 mg


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IL1RL1


dry ice

No


availability

Shipped within 5-7 working days.


alias

IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V


note

This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.


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