Human Interleukin 1 Receptor Like Protein 1 (IL1RL1) Protein
Pida mas información
935106861
info@markelab.com
Precio
225€ (10 µg)
Protein IL1RL1
proveedor
Abbexareference
abx067413Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Interleukin 1 Receptor Like Protein 1 (IL1RL1) is a recombinant Human protein produced in E. coli using Prokaryotic expression.
Background
IL1RL1, also known as ST2, is a member of the IL-1 receptor family that serves as the receptor for interleukin-33 (IL-33), a cytokine involved in type 2 immune responses, tissue repair, and inflammation. IL1RL1 exists in both membrane-bound and soluble isoforms, where the membrane-bound form (ST2L) mediates IL-33 signaling, while the soluble form (sST2) acts as a decoy receptor to neutralize IL-33 activity. Upon IL-33 binding, IL1RL1 forms a heterodimeric complex with IL1RAP, leading to the activation of NF-κB, ERK, and p38 MAPK signaling pathways, which promote cytokine production and immune cell activation. IL1RL1 is highly expressed on Th2 cells, mast cells, eosinophils, and innate lymphoid cells, where it regulates allergic inflammation, tissue homeostasis, and host defense. Dysregulation of IL1RL1 is implicated in allergic asthma, atopic dermatitis, cardiovascular diseases, and fibrotic disorders, where excessive IL-33 signaling drives pathological inflammation and tissue remodeling. Functional studies show that loss of IL1RL1 results in impaired type 2 immune responses, reduced cytokine production, and defective tissue repair, emphasizing its role in immune regulation, inflammation, and tissue homeostasis.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Interleukin 1 Receptor Like Protein 1 (IL1RL1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IL1RL1
dry ice
No
availability
Shipped within 5-7 working days.
alias
IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V
uniprot id
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
Human IL1RL1(Interleukin-1 receptor-like 1) ELISA Kit
proveedor
FineTestreference
EH0188reactivity
humanstatus
RUOPrecio a consultar
Ver másRat IL1RL1(IL-1 Receptor Like 1) ELISA Kit
proveedor
FineTestreference
ER1567reactivity
ratstatus
RUOPrecio a consultar
Ver másInterleukin 1 Receptor Like Protein 1 (IL1RL1) Antibody
proveedor
Abbexareference
abx019114Tested Applications
WBreactivity
Mousestatus
RUOclonality
PolyclonalIL1RL1 Antibody is a Rabbit Polyclonal antibody against Mouse.
300€ (100 µg)
Ver más