Human Interleukin 1 Receptor Like Protein 1 (IL1RL1) Protein
2366€ (1 mg)
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935106861
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name
Human Interleukin 1 Receptor Like Protein 1 (IL1RL1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067412
tested applications
WB, SDS-PAGE
Description
Human Interleukin 1 Receptor Like Protein 1 (IL1RL1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 1 Receptor Like Protein 1 (IL1RL1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 22.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: His162-Ile349 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q01638 |
| Gene ID | 9173 |
| OMIM | 601203 |
| Alias | IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V |
| Background | Protein IL1RL1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL1RL1, also known as ST2, is a member of the IL-1 receptor family that serves as the receptor for interleukin-33 (IL-33), a cytokine involved in type 2 immune responses, tissue repair, and inflammation. IL1RL1 exists in both membrane-bound and soluble isoforms, where the membrane-bound form (ST2L) mediates IL-33 signaling, while the soluble form (sST2) acts as a decoy receptor to neutralize IL-33 activity. Upon IL-33 binding, IL1RL1 forms a heterodimeric complex with IL1RAP, leading to the activation of NF-κB, ERK, and p38 MAPK signaling pathways, which promote cytokine production and immune cell activation. IL1RL1 is highly expressed on Th2 cells, mast cells, eosinophils, and innate lymphoid cells, where it regulates allergic inflammation, tissue homeostasis, and host defense. Dysregulation of IL1RL1 is implicated in allergic asthma, atopic dermatitis, cardiovascular diseases, and fibrotic disorders, where excessive IL-33 signaling drives pathological inflammation and tissue remodeling. Functional studies show that loss of IL1RL1 results in impaired type 2 immune responses, reduced cytokine production, and defective tissue repair, emphasizing its role in immune regulation, inflammation, and tissue homeostasis.
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