Human Interleukin 1 Delta (FIL1d) Protein

Este producto es parte de IL36RN - Interleukin-36 receptor antagonist protein
Product Graph
2938€ (1 mg)

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935106861
info@markelab.com
name
Human Interleukin 1 Delta (FIL1d) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx655701
tested applications
WB, SDS-PAGE

Description

Human Interleukin 1 Delta (FIL1d) Protein (Active) is an Active Recombinant Human protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Interleukin 1 Delta (FIL1d)
Origin
Human
Conjugation
Unconjugated
Observed MW
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
1 mg
Size 2
5 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 1-2 months.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
IL-36Ra,IL-1F5,FIL1, FIL1Delta,IL1F5
Background
Protein IL36RN
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

IL36RN, also known as IL-36Ra, is an anti-inflammatory cytokine that functions as a natural inhibitor of IL-36 signaling. It binds to the IL-36 receptor (IL1RL2) and prevents its activation by IL36A, IL36B, and IL36G, thereby blocking downstream NF-κB, MAPK, and JNK signaling pathways. IL36RN is primarily expressed in keratinocytes, epithelial cells, and immune cells, where it regulates inflammation and prevents excessive immune activation at epithelial barriers. It plays a key role in maintaining tissue homeostasis and limiting pathological inflammation in conditions such as psoriasis, where mutations in IL36RN lead to uncontrolled IL-36 activity, severe inflammation, and pustular psoriasis. IL36RN is also implicated in mucosal immunity and inflammatory diseases of the skin, lungs, and gastrointestinal tract. Knockout studies reveal heightened IL-36 signaling, excessive cytokine production, and severe tissue inflammation, underscoring IL36RN's role as a key anti-inflammatory regulator and protective factor in immune homeostasis and barrier tissue health.

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