Human Interferon Beta (IFNb) Protein

Product specifications

Proteins and Peptides

Interferon Beta (IFNb)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 23.7 kDa  Observed MW (SDS-PAGE): 25 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Met22-Asn187
Tag: N-terminal His tag

Recombinant

> 98%

50 µg

100 µg

200 µg

500 µg

1 mg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

P01574

3456

IFB,IFF,IFNB,IFN-beta,IFN-beta 1,Fibroblast interferon 1,IFNB1

Protein IFNB1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Interferon Beta 1 (IFNB1) is a type I interferon with a critical role in antiviral defense and immunoregulation. Produced predominantly by fibroblasts, epithelial cells, and macrophages, IFNB1 is rapidly secreted in response to viral infections and pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors, such as Toll-like receptors (TLRs). Upon secretion, IFNB1 binds to the interferon alpha/beta receptor (IFNAR), triggering the JAK-STAT signaling pathway. This leads to the transcription of interferon-stimulated genes (ISGs), which orchestrate antiviral responses, including the inhibition of viral replication, degradation of viral RNA, and promotion of apoptosis in infected cells. IFNB1 also enhances antigen presentation by upregulating major histocompatibility complex (MHC) class I molecules and bolsters the activation and proliferation of natural killer (NK) cells and cytotoxic T lymphocytes. Clinically, recombinant forms of IFNB1 are widely used in the treatment of multiple sclerosis (MS), where they modulate the inflammatory response and reduce disease progression. Its role in other autoimmune and infectious diseases continues to be an area of active research.

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