Human Interferon Alpha (IFNa) Protein

Este producto es parte de IFNA1 - interferon alpha 1
Human Interferon Alpha (IFNa) Protein

Pida mas información

935106861

info@markelab.com

Precio

559€ (50 µg)

Protein IFNA1

proveedor

Abbexa

reference

abx651506

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Interferon Alpha (IFNa) Protein is a Human protein produced in 293F cell.


Background

Interferon Alpha 1 (IFNA1) plays a critical role in the body's innate immune response to viral infections. It is a member of the type I interferon family and is produced by cells such as macrophages, dendritic cells, and lymphocytes in response to pathogenic challenges, including viral RNA or DNA. IFNA1 binds to the interferon-alpha/beta receptor (IFNAR) on target cells, triggering a signaling cascade that activates the JAK-STAT pathway. This leads to the transcription of numerous interferon-stimulated genes, enhancing antiviral defense mechanisms by inhibiting viral replication, promoting apoptosis of infected cells, and activating immune cells like NK cells and cytotoxic T lymphocytes. IFNA1 also plays a role in modulating the adaptive immune response by enhancing antigen presentation. Dysregulation of IFNA1 has been implicated in autoimmune conditions such as systemic lupus erythematosus (SLE), and recombinant forms of IFNA1 are used therapeutically for conditions like hepatitis B and C and certain cancers.

Características del producto

category

Proteins and Peptides


origin

Human


host

293F cell


immunogen target

Interferon Alpha (IFNa)


host

293F cell


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

50 µg


size 2

100 µg


size 3

200 µg


size 4

500 µg


size 5

1 mg


observerd MW

Molecular Weight: Calculated MW: 19.8 kDa Observed MW: 20 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Cys24-Leu181 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IFNA1


dry ice

No


availability

Shipped within 5-7 working days.


alias

IFL,IFN,IFNA@,IFNA13,leIF D,IFN-ALPHA,IFN-alphaD,IFN-alpha-1/13,Interferon alpha-D


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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