Human Interferon Alpha (IFNa) Protein
221€ (10 µg)
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name
Human Interferon Alpha (IFNa) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067317
tested applications
WB, SDS-PAGE
Description
Recombinant Interferon alpha is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interferon Alpha (IFNa) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 48.2 kDa Observed MW (SDS-PAGE): 48 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Cys24-Leu181 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01562 |
| Alias | IFL,IFN,IFNA@,IFNA13,leIF D,IFN-ALPHA,IFN-alphaD,IFN-alpha-1/13,Interferon alpha-D |
| Background | Protein IFNA1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Interferon Alpha 1 (IFNA1) plays a critical role in the body's innate immune response to viral infections. It is a member of the type I interferon family and is produced by cells such as macrophages, dendritic cells, and lymphocytes in response to pathogenic challenges, including viral RNA or DNA. IFNA1 binds to the interferon-alpha/beta receptor (IFNAR) on target cells, triggering a signaling cascade that activates the JAK-STAT pathway. This leads to the transcription of numerous interferon-stimulated genes, enhancing antiviral defense mechanisms by inhibiting viral replication, promoting apoptosis of infected cells, and activating immune cells like NK cells and cytotoxic T lymphocytes. IFNA1 also plays a role in modulating the adaptive immune response by enhancing antigen presentation. Dysregulation of IFNA1 has been implicated in autoimmune conditions such as systemic lupus erythematosus (SLE), and recombinant forms of IFNA1 are used therapeutically for conditions like hepatitis B and C and certain cancers.
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