Human Interferon Alpha 2 (IFNa2) Protein
247€ (10 µg)
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Name
Human Interferon Alpha 2 (IFNa2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx067329
Tested Applications
WB, SDS-PAGE
Description
Human Interferon alpha 2 is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Interferon Alpha 2 (IFNa2) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Cys24-Glu188 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 23.0 kDa Observed MW (SDS-PAGE): 23 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01563 |
| Alias | IFNA,leIF A,IFN-alphaA,IFN-alpha-2,Interferon alpha-A,IFNA2A,IFNA2B,IFNA2C |
| Background | Protein IFNA2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Interferon Alpha 2 (IFNA2) is one of the most studied type I interferons due to its significant role in antiviral defense and its clinical applications. Similar to IFNA1, IFNA2 is secreted by immune cells in response to viral infections and engages IFNAR to activate antiviral and immune-modulating pathways. IFNA2 has been extensively utilized in therapeutic settings, including recombinant IFNA2 (e.g., interferon-alpha-2a and -2b) for the treatment of viral hepatitis, certain cancers like melanoma, and hematologic malignancies. It enhances the immune system's ability to combat infections and tumors by promoting immune cell activation, increasing antigen presentation, and inducing apoptosis in infected or malignant cells. However, its use is often associated with side effects like flu-like symptoms and immune dysregulation, necessitating careful administration and monitoring.
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