Human Interferon Alpha 14 (IFNa14) Protein

Product specifications

Proteins and Peptides

Interferon Alpha 14 (IFNa14)

Human

Unconjugated

Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag

Recombinant

> 90%

1 mg

5 mg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.

Shipped within 1-2 months.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

LEIF2H,IFN-alphaH,FN-alpha-14,Interferon lambda-2-H,Interferon alpha-H,LeIF H

Protein IFNA14

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Interferon Alpha 14 (IFNA14) is an integral member of the type I interferon family and contributes significantly to the immune system's antiviral defense. Like other alpha interferons, IFNA14 is secreted by plasmacytoid dendritic cells, monocytes, and other immune cells in response to viral infections, particularly during the early stages. Once released, IFNA14 binds to the interferon alpha/beta receptor (IFNAR) on the surface of various cell types, initiating a signaling cascade through the JAK-STAT pathway. This leads to the transcription of numerous interferon-stimulated genes, which are crucial for antiviral activities, such as halting viral replication, promoting apoptosis in infected cells, and enhancing antigen presentation to T cells. Furthermore, IFNA14 aids in the activation and proliferation of natural killer (NK) cells and cytotoxic T lymphocytes, strengthening the immune system's ability to target and eliminate infected cells. Its specific role within the alpha interferon family may involve unique expression patterns or targeted immune functions, though further research is needed to fully delineate its contributions to immunity and potential clinical applications.

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