Human Intercellular Adhesion Molecule 1 (ICAM1) Protein
351€ (10 µg)
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935106861
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name
Human Intercellular Adhesion Molecule 1 (ICAM1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx682027
tested applications
SDS-PAGE
Description
Human Intercellular Adhesion Molecule 1 (ICAM1) Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Intercellular Adhesion Molecule 1 (ICAM1) |
| Host | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 10-20 working days. |
| Storage | Aliquot and store at -20 °C. |
| Dry Ice | No |
| UniProt ID | P05362 |
| Alias | BB2,CD54,P3.58,ICAM-1 |
| Background | Protein ICAM1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Intercellular Adhesion Molecule 1 (ICAM-1) is a protein encoded by the ICAM1 gene in humans. It plays a crucial role in the immune response by aiding in the adhesion of leukocytes to the endothelial cells lining blood vessels. ICAM-1. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium. ICAM-1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, and a carboxy-terminus cytoplasmic domain. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein’s extracellular domain is composed of multiple loops created by disulfide bridges within the protein. ICAM-1 is important for the process of leukocyte extravasation, which is how white blood cells move from the bloodstream to infected or injured tissues. It helps leukocytes stick to endothelial cells, a crucial step in the inflammatory response. ICAM-1 can also trigger intracellular signaling events when it binds to its ligands, influencing cellular processes related to inflammation and immune responses.
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