Human Integrin Beta 1 (ITGb1) Protein
195€ (10 µg)
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Name
Human Integrin Beta 1 (ITGb1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx067287
Tested Applications
WB, SDS-PAGE
Description
Human Integrin Beta 1 (ITGb1) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Integrin Beta 1 (ITGb1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Asp140-Ile383 Tag: N-terminal His tag and GST tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 57.1 kDa Observed MW (SDS-PAGE): 57 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.05% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05556 |
| Gene ID | 3688 |
| OMIM | 135630 |
| Alias | CD29,FNRB,MDF2,VLAB,GPIIA,MSK12,VLA-BETA,Integrin beta-1,Fibronectin receptor subunit beta,Glycoprotein Iia,VLA-4 subunit beta |
| Background | Protein ITGB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
ITGB1, also known as integrin subunit beta 1 or CD29, is a crucial component of integrins, a large family of cell adhesion molecules involved in mediating interactions between cells and the extracellular matrix (ECM). Integrins play a vital role in various cellular processes, including cell adhesion, migration, proliferation, and differentiation. ITGB1, in particular, is an essential β subunit that pairs with multiple α subunits to form a variety of heterodimeric integrins. These integrins facilitate the binding of cells to ECM proteins, such as fibronectin, collagen, and laminin, and are critical for tissue integrity, wound healing, and development. ITGB1 is ubiquitously expressed across many cell types and tissues, including fibroblasts, endothelial cells, epithelial cells, and immune cells, reflecting its broad role in cellular homeostasis and signaling. Its function extends beyond simple adhesion, as ITGB1 integrins are involved in transmitting signals bidirectionally across the cell membrane, influencing cellular behavior based on external cues. Through a process called "outside-in" and "inside-out" signaling, ITGB1 integrins regulate cell motility, polarity, and survival, contributing to embryogenesis, immune responses, and cancer progression.
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