Human Integrin Alpha D / CD11D (ITGAD) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ITGAD
proveedor
Abbexareference
abx067277Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Integrin Alpha D (ITGaD) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ITGAD (integrin subunit alpha D), also known as CD11d, is a member of the integrin family of cell adhesion molecules. Integrins are heterodimeric receptors consisting of an alpha and a beta subunit, which mediate cell-cell and cell-extracellular matrix interactions. ITGAD pairs with the beta-2 integrin subunit (CD18) to form the αDβ2 (CD11d/CD18) integrin. This integrin is predominantly expressed on myeloid cells, including macrophages, dendritic cells, monocytes, and natural killer (NK) cells, as well as certain subpopulations of lymphocytes. ITGAD, as part of the β2 integrin subfamily, plays a critical role in immune responses, particularly in cell adhesion, migration, and phagocytosis. ITGAD is the least well-characterized among the beta-2 integrins, but emerging research has highlighted its significance in specialized immune responses, such as the clearance of apoptotic cells, regulation of inflammation, and leukocyte recruitment to chronic inflammatory sites. Additionally, ITGAD has been implicated in processes such as tissue remodeling and wound healing. Due to its involvement in these crucial immune processes, ITGAD has garnered increasing attention in the study of immune system regulation and pathologies, including chronic inflammation, autoimmune diseases, and cancer.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Integrin Alpha D / CD11D (ITGAD)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 29.0 kDa Observed MW (SDS-PAGE): 29 kDa Concentration: Prior to lyophilization: 400 µg/ml Sequence Fragment: Phe879-Asn1099 Tag: N-terminal His tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ITGAD
dry ice
No
availability
Shipped within 5-7 working days.
alias
ADB2,CD11D,Integrin alpha-D,CD11 antigen-like family member D,Leukointegrin alpha D
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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