Human Insulin Receptor Substrate 1 (IRS1) Protein
208€ (10 µg)
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935106861
info@markelab.com
name
Human Insulin Receptor Substrate 1 (IRS1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx653883
tested applications
WB, SDS-PAGE
Description
Human Insulin Receptor Substrate 1 (IRS1) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Insulin Receptor Substrate 1 (IRS1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 31.6 kDa Observed MW: 32 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp12-Phe264 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | IRS1, HIRS-1, insulin receptor substrate 1 |
| Background | Protein IRS1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IRS1 is a key adaptor protein that mediates insulin and insulin-like growth factor (IGF) signaling by interacting with the insulin receptor (IR) and IGF-1 receptor. Upon receptor activation, IRS1 is phosphorylated on tyrosine residues, recruiting downstream effectors such as PI3K and Grb2 to activate pathways like PI3K/Akt and Ras/MAPK. IRS1 regulates glucose uptake, metabolism, cell growth, and survival, playing a central role in insulin signaling. It is highly expressed in insulin-sensitive tissues like muscle, liver, and adipose. Dysregulation of IRS1 is associated with insulin resistance, obesity, type 2 diabetes, and cancer, where aberrant signaling promotes proliferation and survival. Knockout studies show growth retardation, metabolic abnormalities, and impaired glucose homeostasis, underscoring its importance in metabolism and cellular signaling.
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