Human Insulin Like Growth Factor 2 Receptor (IGF2R) CLIA Kit
643.5€ (96 tests)
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name
Human Insulin Like Growth Factor 2 Receptor (IGF2R) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx195365
tested applications
CLIA
Description
Human Insulin Like Growth Factor 2 Receptor (IGF2R) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Insulin Like Growth Factor 2 Receptor (IGF2R).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Insulin Like Growth Factor 2 Receptor (IGF2R) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 125 pg/ml - 8000 pg/ml |
| Sensitivity | 75 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | Cation-independent mannose-6-phosphate receptor,MPR1,MPRI,CD222,CIMPR,M6P-R,MPR300,CI-M6PR,MPR 300,CI Man-6-P receptor,300 kDa mannose 6-phosphate receptor,IGF-II receptor |
| Background | CLIA Kits IGF2R |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
The insulin-like growth factor 2 receptor (IGF2R) is a multi-functional transmembrane protein primarily known for binding and internalizing insulin-like growth factor 2 (IGF-2). Unlike the insulin-like growth factor 1 receptor (IGF1R), which signals to promote cell proliferation and survival, IGF2R generally acts to limit the bioavailability of IGF-2 and is therefore considered a negative regulator of growth. IGF2R also binds other ligands, including mannose-6-phosphate-tagged proteins, such as lysosomal enzymes, which it transports from the Golgi to lysosomes. This receptor is widely expressed in mammalian tissues and has important roles in development, cellular signaling, and protein trafficking. IGF2R is unique in its signaling capacity, as it lacks intrinsic tyrosine kinase activity. It operates mainly through ligand sequestration, ligand degradation, and the modulation of signaling pathways indirectly by reducing IGF-2 interactions with IGF1R. IGF2R’s role in growth regulation and its involvement in diseases, particularly cancer, has made it a focal point in biomedical research.
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