Human INSR (Insulin receptor) ELISA Kit
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Product specifications
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 78.125-5000pg/ml |
| Sensitivity | 46.875pg/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | P06213 |
| Alias | HHF5,CD220,IR |
| Background | Elisa kits for INSR |
| Status | RUO |
The insulin receptor (INSR) is a transmembrane protein essential for regulating glucose homeostasis, cellular growth, and metabolism. This receptor, which belongs to the receptor tyrosine kinase (RTK) family, is the primary signaling molecule for insulin, a hormone central to controlling blood sugar levels. By binding insulin, the INSR initiates a cascade of signaling pathways that drive glucose uptake, protein synthesis, lipid metabolism, and cell proliferation. Dysregulation of INSR signaling is implicated in various metabolic and endocrine diseases, most notably type 2 diabetes mellitus (T2DM), obesity, and insulin resistance-related disorders. The receptor’s role in modulating these critical physiological processes makes it a focus for therapeutic interventions and research in metabolic diseases.
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This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
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