Human Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) Protein

234€ (10 µg)
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935106861
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name
Human Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166839
tested applications
WB, SDS-PAGE
Description
Myeloid Cell Leukemia Sequence 1, Bcl2 Related Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Induced Myeloid Leukemia Cell Differentiation Protein (MCL1) |
Host | E. coli |
Origin | Human |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 38.3 kDa Observed MW (SDS-PAGE): 38 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg6-Ile328 Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 90% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S Mcl-1, M,bcl2-L-3,mcl1/EAT,Bcl-2-like protein 3,BCL2L3,Bcl-2-related protein EAT/mcl1 |
Background | Protein MCL1 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Induced myeloid leukemia cell differentiation protein MCL1 is an anti-apoptotic protein that plays a critical role in regulating cell survival, particularly in hematopoietic and immune cells Mcl-1 belongs to the Bcl-2 family and helps prevent apoptosis by interacting with pro-apoptotic Bcl-2 family members, inhibiting their activity and preventing mitochondrial outer membrane permeabilization Mcl-1 is essential for the survival of various cell types, including myeloid cells, and its expression is tightly regulated during cell differentiation and immune responses Its dysregulation has been linked to cancer, particularly hematological malignancies, where overexpression of Mcl-1 promotes the survival of malignant cells and contributes to chemotherapy resistance In addition to its role in apoptosis, Mcl-1 is involved in regulating mitochondrial function, cell metabolism, and the stress response Mcl-1’s central role in both cell survival and apoptosis makes it a critical factor in normal cellular function and a potential target for therapeutic intervention in cancer and other diseases related to cell survival regulation
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