Human Importin Subunit Alpha-5 (KPNA1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for KPNA1
proveedor
Abbexareference
abx388198Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Importin Subunit Alpha-5 (KPNA1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human KPNA1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
KPNA1, also known as importin-α1, is a nuclear transport adaptor protein that mediates the import of cargo proteins containing classical nuclear localization signals (NLS) into the nucleus. It forms a heterodimer with importin-β, which facilitates the translocation of the cargo-importin complex through the nuclear pore complex (NPC) via energy-dependent mechanisms. KPNA1 is widely expressed and plays a critical role in nuclear-cytoplasmic transport during processes like transcription regulation, cell cycle progression, and stress responses. KPNA1 is involved in viral infection, where it mediates the nuclear import of viral proteins. Dysregulation of KPNA1 is linked to diseases such as cancer, where altered nuclear transport enhances oncogenic signaling. Knockout studies highlight its role in embryonic development, where impaired KPNA1 function leads to defects in gene regulation and cell growth.
Características del producto
category
ELISA Kits
immunogen target
Importin Subunit Alpha-5 (KPNA1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.06 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
KPNA1,IPOA5, NPI-1, RCH2, SRP1, Importin, Importin subunit alpha-5, karyopherin subunit alpha 1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
KPNA1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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