Human Hydroperoxide Isomerase ALOXE3 (ALOXE3) Protein

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Description
Human Arachidonate Lipoxygenase 3 (ALOXE3) Protein is a Recombinant Human protein expressed in E. coli.
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Product specifications
Category | Proteins and Peptides |
Immunogen Target | Hydroperoxide Isomerase ALOXE3 (ALOXE3) |
Host | E. coli |
Origin | Human |
Conjugation | Unconjugated |
Observed MW | Molecular Weight: Calculated MW: 84.3 kDa Observed MW: 84 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ile711 Tag: N-terminal His tag |
Expression | Recombinant |
Purity | > 90% |
Size 1 | 10 µg |
Size 2 | 50 µg |
Size 3 | 100 µg |
Size 4 | 200 µg |
Size 5 | 500 µg |
Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
Tested Applications | WB, SDS-PAGE |
Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
Availability | Shipped within 5-7 working days. |
Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
Alias | Epidermis-type lipoxygenase 3 |
Background | Protein ALOXE3 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ALOXE3 is a member of the lipoxygenase family that functions as an epidermal lipoxygenase critical for skin barrier formation and maintenance. Unlike other lipoxygenases, ALOXE3 acts as a hydroperoxide isomerase, converting epoxyalcohol intermediates into key lipid mediators required for the assembly of the cornified lipid envelope in the epidermis. ALOXE3 is specifically expressed in the skin and is essential for proper lipid metabolism during keratinocyte differentiation. Mutations in the ALOXE3 gene are linked to autosomal recessive congenital ichthyosis (ARCI), a disorder characterized by dry, scaly skin due to defective epidermal lipid processing and barrier dysfunction. In addition to its role in skin biology, ALOXE3 may contribute to anti-inflammatory pathways by regulating lipid signaling in epithelial tissues. Emerging research suggests that ALOXE3 dysfunction may influence wound healing, oxidative stress responses, and epithelial tissue repair. Its unique enzymatic activity makes it essential for skin homeostasis and a potential therapeutic target for treating barrier-related skin diseases.
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