Human Hydroperoxide Isomerase ALOXE3 (ALOXE3) Protein

Este producto es parte de ALOX - Arachidonate lipoxygenase
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208€ (10 µg)

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935106861
info@markelab.com
name
Human Hydroperoxide Isomerase ALOXE3 (ALOXE3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652574
tested applications
WB, SDS-PAGE

Description

Human Arachidonate Lipoxygenase 3 (ALOXE3) Protein is a Recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Hydroperoxide Isomerase ALOXE3 (ALOXE3)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 84.3 kDa  Observed MW: 84 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Met1-Ile711
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
Epidermis-type lipoxygenase 3
Background
Protein ALOXE3
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ALOXE3 is a member of the lipoxygenase family that functions as an epidermal lipoxygenase critical for skin barrier formation and maintenance. Unlike other lipoxygenases, ALOXE3 acts as a hydroperoxide isomerase, converting epoxyalcohol intermediates into key lipid mediators required for the assembly of the cornified lipid envelope in the epidermis. ALOXE3 is specifically expressed in the skin and is essential for proper lipid metabolism during keratinocyte differentiation. Mutations in the ALOXE3 gene are linked to autosomal recessive congenital ichthyosis (ARCI), a disorder characterized by dry, scaly skin due to defective epidermal lipid processing and barrier dysfunction. In addition to its role in skin biology, ALOXE3 may contribute to anti-inflammatory pathways by regulating lipid signaling in epithelial tissues. Emerging research suggests that ALOXE3 dysfunction may influence wound healing, oxidative stress responses, and epithelial tissue repair. Its unique enzymatic activity makes it essential for skin homeostasis and a potential therapeutic target for treating barrier-related skin diseases.

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