Human Hydroperoxide Isomerase ALOXE3 (ALOXE3) ELISA Kit

Este producto es parte de ALOX - Arachidonate lipoxygenase
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715€ (96 tests)

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935106861
info@markelab.com
name
Human Hydroperoxide Isomerase ALOXE3 (ALOXE3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx150621
tested applications
ELISA

Description

Human Hydroperoxide Isomerase ALOXE3 (ALOXE3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Hydroperoxide Isomerase ALOXE3 (ALOXE3) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Arachidonate Lipoxygenase 3 (ALOXE3)

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Hydroperoxide Isomerase ALOXE3 (ALOXE3)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.312 ng/ml - 20 ng/ml
Sensitivity
< 0.12 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates and other biological fluids.
Availability
Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
Epidermis-type lipoxygenase 3
Background
Elisa kits for ALOXE3
Status
RUO
Note
Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ALOXE3 is a member of the lipoxygenase family that functions as an epidermal lipoxygenase critical for skin barrier formation and maintenance. Unlike other lipoxygenases, ALOXE3 acts as a hydroperoxide isomerase, converting epoxyalcohol intermediates into key lipid mediators required for the assembly of the cornified lipid envelope in the epidermis. ALOXE3 is specifically expressed in the skin and is essential for proper lipid metabolism during keratinocyte differentiation. Mutations in the ALOXE3 gene are linked to autosomal recessive congenital ichthyosis (ARCI), a disorder characterized by dry, scaly skin due to defective epidermal lipid processing and barrier dysfunction. In addition to its role in skin biology, ALOXE3 may contribute to anti-inflammatory pathways by regulating lipid signaling in epithelial tissues. Emerging research suggests that ALOXE3 dysfunction may influence wound healing, oxidative stress responses, and epithelial tissue repair. Its unique enzymatic activity makes it essential for skin homeostasis and a potential therapeutic target for treating barrier-related skin diseases.

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