Human HTR7 (5-hydroxytryptamine receptor 7) ELISA Kit
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Name
Human HTR7 (5-hydroxytryptamine receptor 7) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH4496
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | P34969 |
| Alias | HTR7,5-HT7,5-HT7 receptor |
| Background | Elisa kits for HTR7 |
| Status | RUO |
Background
HTR7 is a serotonin receptor belonging to the G protein-coupled receptor (GPCR) family that activates adenylate cyclase upon binding to serotonin (5-HT), leading to increased cAMP production. It is widely expressed in the central nervous system, including the thalamus, hypothalamus, hippocampus, and the spinal cord, where it regulates critical functions such as mood, circadian rhythms, sleep, and thermoregulation. HTR7 is also expressed in peripheral tissues, including the gastrointestinal tract and vascular smooth muscles, where it modulates gut motility and vascular tone. Dysregulation of HTR7 signaling has been linked to mood disorders such as depression and bipolar disorder, as well as to sleep disturbances and migraine pathophysiology. Additionally, HTR7 has been implicated in inflammatory diseases and neurodevelopmental disorders due to its influence on neuronal connectivity and immune responses. Pharmacologically, selective HTR7 antagonists have demonstrated antidepressant and anxiolytic effects, making the receptor an attractive target for mood disorder therapies. Furthermore, HTR7 has potential roles in the management of pain and migraine, given its regulatory function in the pain processing pathways. Its broad physiological roles underscore its importance in maintaining neurological homeostasis and suggest therapeutic opportunities in both CNS disorders and systemic diseases.
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