Human HTR3A (5-hydroxytryptamine receptor 3A) ELISA Kit
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Name
Human HTR3A (5-hydroxytryptamine receptor 3A) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH9252
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | P46098 |
| Alias | HTR3A,HTR3, 5HT3R, 5-HT-3, 5-HT3A, 5-HT3R,5-HT3A receptor |
| Background | Elisa kits for HTR3A |
| Status | RUO |
Background
HTR3A is a subunit of the 5-HT3 receptor, a ligand-gated ion channel receptor that differs from the G protein-coupled serotonin receptors (5-HT1, 2, etc.). Found primarily in the central nervous system (CNS) and peripheral nervous system (PNS), HTR3A mediates fast excitatory neurotransmission in response to serotonin (5-HT). The receptor's activation allows for the influx of sodium (Na+) and calcium (Ca2+) ions across the neuronal membrane, leading to neuronal depolarization. HTR3A is crucial in regulating physiological processes such as nausea and vomiting, gastrointestinal motility, anxiety, and pain perception. It is highly expressed in the area postrema, a brain region involved in emetic responses. Consequently, 5-HT3 receptor antagonists like ondansetron are used clinically to prevent chemotherapy-induced nausea and vomiting (CINV). In the enteric nervous system, HTR3A modulates peristalsis and visceral pain, making it relevant for irritable bowel syndrome (IBS) treatment. Dysregulation of HTR3A function has also been implicated in neuropsychiatric disorders, including anxiety, depression, and schizophrenia. Genetic polymorphisms of HTR3A have been associated with heightened anxiety sensitivity and increased risk of mood disorders, indicating its therapeutic importance in both gastrointestinal and neurological contexts.
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