Human Histamine H2 Receptor (HRH2) ELISA Kit

Este producto es parte de HRH - histamine receptor H
Human Histamine H2 Receptor (HRH2) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for HRH2

proveedor

Abbexa

reference

abx387883

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Histamine H2 Receptor (HRH2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human HRH2 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

HRH2 is a G protein-coupled receptor activated by histamine, primarily expressed in gastric parietal cells, smooth muscle cells, and immune cells. HRH2 couples to Gs proteins, activating adenylyl cyclase, increasing cAMP levels, and promoting protein kinase A (PKA)-mediated signaling. In the stomach, HRH2 regulates gastric acid secretion by stimulating parietal cells, making it a key target for managing acid-related disorders such as gastroesophageal reflux disease (GERD) and peptic ulcers. HRH2 also plays roles in immune regulation, where its activation suppresses pro-inflammatory cytokine production and modulates T-cell responses. In the cardiovascular system, HRH2 induces vasodilation and regulates heart rate. Dysregulation of HRH2 contributes to hyperacidity, gastric ulcers, and inflammatory diseases. HRH2 antagonists, such as ranitidine and famotidine, are widely used as acid-suppressive therapies. HRH2 also has a role in cancer progression, where its expression influences tumor cell proliferation and immune evasion, particularly in gastrointestinal cancers.

Características del producto

category

ELISA Kits


immunogen target

Histamine H2 Receptor (HRH2)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.094 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

HRH2,gastric receptor I,H2R,HH2R


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

HRH2


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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