Human Growth Factor Receptor Bound Protein 7 (Grb7) Protein
234€ (10 µg)
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Name
Human Growth Factor Receptor Bound Protein 7 (Grb7) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx066955
Tested Applications
WB, SDS-PAGE
Description
Human Growth Factor Receptor Bound Protein 7 (GRB7) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Growth Factor Receptor Bound Protein 7 (Grb7) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ser66-Thr327 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 33.1 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14451 |
| Alias | GRB7, entrez:2886, growth factor receptor bound protein 7 |
| Background | Protein GRB7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
GRB7 is an adaptor protein that interacts with receptor tyrosine kinases (RTKs) like HER2, VEGFR, and IGF1R, linking them to downstream signaling pathways such as Ras/MAPK, PI3K/Akt, and focal adhesion kinase (FAK). GRB7 contains SH2, PH, and proline-rich domains, enabling its localization to membranes and interactions with signaling molecules involved in cell migration, adhesion, and proliferation. GRB7 is highly expressed in cancers, particularly HER2-positive breast cancer, ovarian cancer, and esophageal carcinoma, where it promotes tumor progression, metastasis, and angiogenesis. It also regulates integrin-mediated signaling pathways, playing roles in cell spreading and cytoskeletal organization. GRB7 dysregulation is associated with poor clinical outcomes in cancer patients due to its role in enhancing cell motility and survival. Knockdown studies show reduced tumor cell invasion, highlighting its potential as a therapeutic target in metastatic cancers.
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