Human Growth Factor Receptor Bound Protein 7 (Grb7) ELISA Kit
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935106861
info@markelab.com
Precio
546€ (96 tests)
Elisa kits for GRB7
proveedor
Abbexareference
abx157132Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Growth Factor Receptor Bound Protein 7 (Grb7) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Growth Factor Receptor Bound Protein 7 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
GRB7 is an adaptor protein that interacts with receptor tyrosine kinases (RTKs) like HER2, VEGFR, and IGF1R, linking them to downstream signaling pathways such as Ras/MAPK, PI3K/Akt, and focal adhesion kinase (FAK). GRB7 contains SH2, PH, and proline-rich domains, enabling its localization to membranes and interactions with signaling molecules involved in cell migration, adhesion, and proliferation. GRB7 is highly expressed in cancers, particularly HER2-positive breast cancer, ovarian cancer, and esophageal carcinoma, where it promotes tumor progression, metastasis, and angiogenesis. It also regulates integrin-mediated signaling pathways, playing roles in cell spreading and cytoskeletal organization. GRB7 dysregulation is associated with poor clinical outcomes in cancer patients due to its role in enhancing cell motility and survival. Knockdown studies show reduced tumor cell invasion, highlighting its potential as a therapeutic target in metastatic cancers.
Características del producto
category
ELISA Kits
immunogen target
Growth Factor Receptor Bound Protein 7 (Grb7)
reactivity
Human
test range
62.5 pg/ml - 4000 pg/ml
sensitivity
37.5 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
GRB7, entrez:2886, growth factor receptor bound protein 7
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
GRB7
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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