Human GRB2 Related Adaptor Protein (GRAP) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for GRAP
proveedor
Abbexareference
abx387669Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human GRB2 Related Adaptor Protein (GRAP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human GRB2 Related Adapter Protein concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
GRAP is an adaptor protein similar to GRB2, containing SH2 and SH3 domains that mediate protein-protein interactions between receptor tyrosine kinases and intracellular signaling molecules. It is primarily expressed in hematopoietic and immune cells, where it plays a critical role in T-cell receptor (TCR) and cytokine receptor signaling pathways, including MAPK/ERK, JNK, and calcium mobilization cascades. GRAP functions as a scaffold protein, recruiting signaling molecules like SOS, PLCγ, and SHC to facilitate pathways that regulate cell proliferation, survival, and differentiation. It supports immune cell activation, lymphocyte development, and adaptive immune responses. Dysregulation of GRAP impairs immune signaling, leading to defects in T-cell activation, cytokine production, and immune homeostasis. It is particularly important in balancing immune responses to prevent overactivation or immunodeficiency. Knockout studies emphasize its role in TCR signaling, showing defects in T-cell proliferation and response to antigenic stimulation.
Características del producto
category
ELISA Kits
immunogen target
GRB2 Related Adaptor Protein (GRAP)
reactivity
Human
test range
0.313 ng/ml - 20 ng/ml
sensitivity
< 0.188 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
GRAP, GRB2-related adaptor protein, GRB2 related adaptor protein, DFNB114
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
GRAP
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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