GRB2 Related Adaptor Protein (GRAP) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
GRB2 Related Adaptor Protein (GRAP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx233634
tested applications
ELISA, WB, IHC
Description
GRAP Antibody is a Rabbit Polyclonal against GRAP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | GRB2 Related Adaptor Protein (GRAP) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/200 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13588 |
| Gene ID | 10750 |
| OMIM | 604330 |
| Alias | GRAP, GRB2-related adaptor protein, GRB2 related adaptor protein, DFNB114 |
| Background | Antibody anti-GRAP |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
GRAP is an adaptor protein similar to GRB2, containing SH2 and SH3 domains that mediate protein-protein interactions between receptor tyrosine kinases and intracellular signaling molecules. It is primarily expressed in hematopoietic and immune cells, where it plays a critical role in T-cell receptor (TCR) and cytokine receptor signaling pathways, including MAPK/ERK, JNK, and calcium mobilization cascades. GRAP functions as a scaffold protein, recruiting signaling molecules like SOS, PLCγ, and SHC to facilitate pathways that regulate cell proliferation, survival, and differentiation. It supports immune cell activation, lymphocyte development, and adaptive immune responses. Dysregulation of GRAP impairs immune signaling, leading to defects in T-cell activation, cytokine production, and immune homeostasis. It is particularly important in balancing immune responses to prevent overactivation or immunodeficiency. Knockout studies emphasize its role in TCR signaling, showing defects in T-cell proliferation and response to antigenic stimulation.
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